2019 Protein Modeling

Protein Modeling – 9/19/18 (Division C) Two changes:

1. DESCRIPTION, should read, edits in bold: Students will use computer visualization and online resources to construct physical models of the CRISPR Cas9 protein and Anti-CRISPR protein that are being engineered to edit plant and animal cell genomes, and answer a series of questions about the chemistry of protein folding and the interaction of structure and function for model proteins.

3. THE COMPETITION Part I: The Pre-Built Model, a. should read, edits in bold: Participants will use the program Jmol/JSmol to visualize a model of residues 1-85 of the Anti-CRISPR protein, based on the coordinate data found in the 5vw1.pdb file. The 5vw1.pdb file can be accessed for free from the RCSB Protein Data Bank (www.rcsb.org). Jmol/JSmol can be accessed here for free.

Protein Modeling – 1/11/19 (Division C) 2a. should read, edits in bold: Each team must bring pencils or pens for the exam, a marker for marking the toobers, a metric ruler with cm marks, and one 8.5” x 11” sheet of paper that may contain information on both sides in any form and from any source. This sheet may be contained in a sheet protector or laminated.